Research & Innovation

91��Ƶ researcher explores novel biomaterials to improve the treatment of chronic diseases

Christopher.Sorensen — Thu, 03 Oct 2024 15:08:08 +0000

91��Ƶ researcher explores novel biomaterials to improve the treatment of chronic diseases

Christopher.Sorensen Thu, 10/03/2024 - 11:08

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91��Ƶ researcher Caitlin Maikawa and her team are hoping to ease the burden on patients by developing more treatments for chronic diseases that can be self-administered in the home (photo by Tim Fraser)

Selah Katona

Topic

Our Community

Institute of Biomedical Engineering

Faculty of Applied Science & Engineering

Research & Innovation

Subheadline

“It’s our goal to develop technologies, such as a pill, that make disease management easier and more effective so that it easily fits into patient’s lifestyles"

A team of researchers at the 91��Ƶ is researching how to develop a pill to deliver treatment of chronic diseases that are currently managed by medications administered by injection.

Led by Caitlin Maikawa, the team aims to increase the accessibility of treatment by removing the burden on patients who are required to visit their doctor’s office to receive medication.

“Taking a pill is the patient-preferred method of administration since it gives them autonomy over their treatment and the ability to easily do it themselves at home,” says Maikawa, an assistant professor at the Institute for Biomedical Engineering in the Faculty of Applied Science & Engineering.

“We hope our research will lead to new technologies that will improve the efficacy of current therapeutics and reduce the patient burden associated with managing chronic diseases.” 

Maikawa is one of two 91��Ƶ Engineering professors to receive funding from the latest round of the Canadian Foundation for Innovation John R. Evans Leaders Fund (CFI-JELF). The other recipient is Mohamad Moosavi, an assistant professor of chemical engineering and applied chemistry, whose research incorporates artificial intelligence to accelerate the discovery of new materials to combat climate change.

The support will help Maikawa’s lab engineer dynamic polymer biomaterial systems to develop new drug delivery and bio-sensing technologies to treat chronic diseases, including inflammatory bowel disease and diabetes.

Polymers are large molecules composed of repeating structural units that can be designed to interact with disease markers in the body to target therapeutics to disease sites, time the release of therapeutics or even release signalling molecules for disease monitoring.

(photo by Tim Fraser)

Maikawa’s research group focuses on the design and synthesis of dynamic polymer systems by using stimuli-responsive chemistries, also known as affinity-based interactions – a concept where certain molecules respond to external stimuli and interact selectively with a particular substance – and applying these polymer materials to address challenges in treating chronic disease.

“One way of thinking about dynamic polymer systems is that we have a kind of molecular Velcro where these molecular units stick together when we make the material,” says Maikawa. “But in the presence of disease markers in the body, the Velcro pulls apart allowing the material to degrade or in some cases to release the drug.”

Maikawa’s lab aims to collaborate with clinicians to understand how to address impactful challenges with biomaterials. Since chronic diseases are often difficult to manage, her team is looking at the whole picture of chronic disease treatment and its efficacy.

“It’s our goal to develop technologies, such as a pill, that make disease management easier and more effective so that it easily fits into patient’s lifestyles,” she says.

91��Ƶ ranked 13th on list of 50 schools transforming entrepreneurship: Fast Company

Christopher.Sorensen — Thu, 03 Oct 2024 15:01:18 +0000

91��Ƶ ranked 13th on list of 50 schools transforming entrepreneurship: Fast Company

Christopher.Sorensen Thu, 10/03/2024 - 11:01

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(photo by Polina Teif)

Topic

Global Lens

91��Ƶ Entrepreneurship

Innovation & Entrepreneurship

Rankings

Research & Innovation

Startups

The 91��Ƶ has earned the 13th spot in a new ranking by Inc. and Fast Company magazines that highlights the top 50 institutions transforming entrepreneurship.

The Ignition Schools list highlights academic institutions from around the world with the biggest impact on business and ideas that define the future, writes Brendan Vaughan, the editor-in-chief of Fast Company. He said the 50 schools in the inaugural list “don’t just produce elite students and groundbreaking research; they also are economic engines that generate the ideas, businesses, and opportunities that move cities, regions, and countries toward a better future.”

The list’s methodology assesses how the schools foster new technologies and industries while nurturing the individuals and companies that bring them to market. Out of a pool of approximately 900 institutions, schools were scored based on factors such as their performance in producing founders and entrepreneurs, companies launched by students and alumni and the amount of venture capital raised.

Having created more than 650 companies with the support of 12 accelerators, 91��Ƶ was the highest ranked Canadian university on the Ignition Schools list.

AI tool reduces risk of unexpected hospital deaths by 26 per cent: Study

Christopher.Sorensen — Mon, 23 Sep 2024 16:50:13 +0000

AI tool reduces risk of unexpected hospital deaths by 26 per cent: Study

Christopher.Sorensen Mon, 09/23/2024 - 12:50

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(photo by Tempura/Getty Images)

Adam Miller

Topic

Our Community

Temerty Faculty of Medicine

Unity Health

Artificial Intelligence

Research & Innovation

St. Michael's Hospital

Subheadline

CHARTWatch, an artificial intelligence early warning system developed at Unity Health Toronto, alerts physicians when hospital patients face a high risk of unexpected death or transfer to an ICU

A new study by Toronto researchers evaluates the use of CHARTWatch, an artificial intelligence early warning system developed at Unity Health Toronto that monitors hospitalized patients in real-time, identifies those at high risk of unexpected death or transfer to an intensive care unit, and alerts doctors and nurses to intervene early.

The study, published in the Canadian Medical Association Journal, shows a 26 per cent reduction in unanticipated mortality after the tool was implemented in the general internal medicine ward of Unity Health Toronto’s St. Michael’s Hospital.

“As AI tools are increasingly being used in medicine, it is important that they are evaluated carefully to ensure that they are safe and effective,” says lead author Amol Verma, general internist at Unity Health and professor in the department of medicine in the 91��Ƶ’s Temerty Faculty of Medicine who led the development and implementation of CHARTWatch.

Amol Verma (L) and Muhammad Mamdani (supplied images)

“Our findings suggest that AI-based early warning systems are promising for reducing unexpected deaths in hospitals.”

One of the primary sources of unplanned admission to the ICU is the unexpected deterioration of hospitalized patients, which prompted the research team to develop this AI tool and study its effectiveness.

“This important study evaluates the outcomes associated with the complex deployment of the entire AI solution, which is critical to understanding the real-world impacts of this promising technology,” says study co-author Muhammad Mamdani, vice president of data science and advanced analytics at Unity Health and director of 91��Ƶ’s Temerty Centre for Artificial Intelligence Research and Education in Medicine.

“We hope other institutions can learn from and improve upon Unity Health Toronto’s experiences to benefit the patients they serve.”

The study analyzed data from 13,649 patients aged 55 to 80 years old admitted to the general internal medicine unit (9,626 in the pre-intervention period and 4,023 using CHARTWatch) and 8,470 admitted to subspeciality units that did not use CHARTWatch.

Helping to prioritize patient needs

“The CHARTWatch project started at Unity Health when we asked patients, clinicians, hospital leaders, what would you want to use artificial intelligence for? If you could predict one thing that AI would tell you, what should that be?” says Verma, who is also the Temerty Professor of AI Research and Education in Medicine.

“And one of the leading priorities of everyone was to be able to predict in advance which patients might become so sick in hospital that they need ICU or might die.”

During the 19-month-long intervention period, 482 patients in the general internal medicine became high-risk, compared with 1,656 patients who became high risk in the 43-month-long pre-intervention period. There were also fewer non-palliative deaths in the CHARTWatch group than in the pre-intervention group (1.6 per cent versus 2.1 per cent).

“If I were a patient, I would be so relieved to know that we have this kind of system,” said co-author Yuna Lee, division head and general internist at St. Michael’s and professor in the department of medicine at 91��Ƶ.

“So, when the patient gets a high-risk alert, they’re going to be assessed by senior staff right away. Also, they’re going to have quite close monitoring by nursing staff, so they check on them every one to two hours.”

Expanding the impact of CHARTWatch

CHARTWatch inputs more than 100 aspects of a patient’s medical history and current health status that are routinely stored in the hospital’s electronic medical record. It analyzes the interactions between these inputs and how they change over time. With that information, it’s able to categorize each patient by their risk for deterioration and send an alert to prioritize treatment.

The study is one of the first to evaluate how CHARTWatch can benefit hospital patients in Canada and shows the potential real-world impact of AI on the health-care sector. Damian Jankowicz, Unity Health’s vice-president and chief information and AI officer, says he hopes AI tools such as CHARTWatch will continue to have a profound impact on patients.

“Hopefully with reduced administrative burden on our providers, they will have more time to spend with our patients and really focus on the patient needs,” he says.

“I hope that AI will be able to distill the incredible amounts of information that’s coming at our clinicians into important components and really bring their clinical judgment to the forefront.”

This story first was first published by Unity Health.

Battery-powered EV chargers – co-developed at 91��Ƶ – installed on St. George campus

rahul.kalvapalle — Fri, 20 Sep 2024 14:34:25 +0000

Battery-powered EV chargers – co-developed at 91��Ƶ – installed on St. George campus

rahul.kalvapalle Fri, 09/20/2024 - 10:34

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The Level 3+ battery-powered EV charging stations are available in 91��Ƶ's Landmark Garage, located beneath King's College Circle on the St. George campus (photo by Safa Jinje)

Safa Jinje

Topic

Breaking Research

department of mechanical and industrial engineering

Facilities and Services

Faculty of Applied Science & Engineering

Landmark

Sustainability

Subheadline

The rapid-charging stations were developed by Canadian EV tech company Jule in collaboration with experts at the Faculty of Applied Science & Engineering

The historic core of the 91��Ƶ’s St. George campus is now home to a pair of next-generation electric vehicle (EV) charging stations that utilize technology co-developed at the university.

The two new stations use direct current (DC)-sourced EV chargers boasting integrated battery energy storage systems – novel technology that minimizes strain on the electrical grid.

Located in the Landmark Garage beneath King’s College Circle, the chargers are rated Level 3+, meaning they can charge EVs in under 30 minutes, and bring the total number of EV charging stations in the garage to 50.

The technology underpinning the new charges was developed by Jule, an energy storage and EV solutions company co-founded by Faculty of Applied Science & Engineering alumnus Carmine Pizzurro, in collaboration with 91��Ƶ faculty members.

Jule embarked on its first research collaboration with 91��Ƶ shortly after its founding in 2009, teaming up with the Centre for Applied Power Electronics led by Professor Reza Iravani at the Edward S. Rogers Sr. department of electrical and computer engineering.

It also worked closely with the city's electric utility.

“One of our first collaborations was with Toronto Hydro, which led to us being the first company in the world to put lithium-ion batteries on the distribution grid to provide backup power during outages and reduce stress on the grid during peak periods,” says Pizzurro, who earned his bachelor’s and master’s degrees in mechanical engineering at 91��Ƶ.

Cristina Amon and Carlos Da Silva (fourth and fifth from left, respectively, in the front row) pose with students and staff in the Thermal Management Systems lab (photo by Aaron Demeter)

Pizzurro went on to install Jule’s first battery-powered fast chargers in northern Canada as part of a collaboration with Natural Resources Canada.

But the company needed to address a longstanding challenge with lithium-ion batteries: they’re temperature-sensitive and must be able to operate reliably in both hot and cold environments if they are to help power a net-zero future.

To tackle this issue, Jule in 2018 expanded its partnership with the Faculty of Applied Science & Engineering to include University Professor Cristina Amon and senior research associate Carlos Da Silva of the Advanced Thermofluids Optimization, Modelling and Simulation (ATOMS) laboratory in the department of mechanical and industrial engineering.

The ATOMS experts have been developing computational models and experimental characterization to optimize Jule’s battery thermal management systems – work that is being carried out in a state-of-the-art battery testing facility that received funding from the Canada Foundation for Innovation and Ontario Research Fund.

“Thermal management is an issue that impacts both aspects of Jule’s EV fast charging technology: the power electronics to enable the charging, as well as their unique integrated battery storage system,” says Da Silva, who is also executive director of the 91��Ƶ Electrification Hub. “Thermal management is critical for mitigating battery degradation. It requires regulating the temperature in such a way that you keep the battery within an optimal range that will extend its life span.”

Jule’s fast chargers use energy stored in batteries, rather than drawing it directly from the electrical grid in the manner of traditional fast chargers. That means they don’t cause grid overloading during peak usage times and can be charged during off-peak hours when electricity is less costly; they also don’t require significant investments in electricity upgrades.

“The battery storage system is charged using current from the electrical grid, which is alternating current (AC); and then this larger battery, which uses direct current (DC), charges the smaller battery in the electric vehicle,” says Amon. “It is more efficient to fast-charge from a stationary battery to an EV – DC to DC – than it is to fast-charge an EV from the electrical grid, which requires converting AC to DC power.”

Jule’s Level 3+ charging station can provide up to 200 kilowatts of power output, yet only needs 45 kilowatts of input power. Amon says this rapid charging speed can help alleviate range anxiety among EV users: “Some drivers fear that EV batteries may not have enough energy to reach a desired destination. But if charging time is much closer to the time required to fill up a tank of a gas-powered car, that can reduce this worry.”

L-R: Professor Reza Iravani, Jule co-founder Carmine Pizzurro, 91��Ƶ Electrification Hub Executive Director Carlos Da Silva, University Professor Cristina Amon and 91��Ƶ Engineering Dean Christopher Yip (photo by Safa Jinje)

The Level 3+ stations are joining 48 Level 2 chargers that are already available for public use at the Landmark Garage.

This increases the campus’s charging capacity to over 25,000 charges per year, which can eliminate over 700 tons of greenhouse gas emissions, according to 91��Ƶ’s Sustainability Office.

“Hosting these first-of-their-kind EV chargers right here on campus extends beyond providing a new and exciting sustainability service to our community,” says Ron Saporta, 91��Ƶ’s chief operating officer, property services and sustainability. “It represents just one example of how we are supporting the intersection of research, learning and commercialization of sustainable innovations developed by members of our very own 91��Ƶ community.”

The charging stations will also serve as a living lab to test future thermal innovations jointly developed by 91��Ƶ Engineering researchers and Jule.

“Having these chargers on campus enables us to have a greater capacity to test the system in ways we are limited by doing in a lab setting,” says Da Silva.

Geoscientists confirm 'dripping' of Earth’s crust beneath Türkiye's Central Anatolian Plateau

Christopher.Sorensen — Wed, 18 Sep 2024 10:35:54 +0000

Geoscientists confirm 'dripping' of Earth’s crust beneath Türkiye's Central Anatolian Plateau

Christopher.Sorensen Wed, 09/18/2024 - 06:35

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Earth scientists have identified active sinking at the Konya Basin in Türkiye due to the dripping of lithospheric material beneath the planet’s surface over millions of years (photo by temizyurek/Getty Images)

Sean Bettam

Topic

Breaking Research

Earth Sciences

Faculty of Arts & Science

Global

Research & Innovation

Recent satellite data reveal that the Konya Basin in the Central Anatolian Plateau of Türkiye is continually being reshaped over millions of years, according to a new analysis led by Earth scientists at the 91��Ƶ.

The researchers say experimental simulations – combined with geological, geophysical and geodetic data – explain the enigmatic sinking of the basin within the rising plateau interior and further suggests a new class of plate tectonics that has implications for other planets that do not have Earth-like plates such as Mars and Venus.

The study, published in Nature Communications, shows the sinking in the region is due to multi-stage lithospheric dripping – a phenomenon named for the instability of rocky material that makes up Earth’s crust and upper mantle. As dense rock fragments beneath the surface detach and sink into the more fluid layer of the planet’s mantle, major landforms such as basins and mountainous folding of the crust form at the surface.

“Looking at the satellite data, we observed a circular feature at the Konya Basin where the crust is subsiding or the basin is deepening,” says lead author Julia Andersen, a PhD candidate in 91��Ƶ’s department of Earth sciences in the Faculty of Arts & Science.

“This prompted us to look at other geophysical data beneath the surface where we saw a seismic anomaly in the upper mantle and a thickened crust, telling us there is high-density material there and indicating a likely mantle lithospheric drip.”

Artist’s impression of the multi-stage lithospheric dripping process in Central Anatolia (illustration by Nevena Niagolova)

The results echo a similar investigation by the researchers into the formation of the Arizaro Basin in the Andes Mountains of South America, suggesting the phenomenon can occur anywhere on the planet and explains tectonic processes typically found within mountain plateau regions.

Past studies show the Central Anatolian Plateau has risen by as much as one kilometre over the past 10 million years because of the lithospheric dripping phenomenon.

“As the lithosphere thickened and dripped below the region, it formed a basin at the surface that later sprang up when the weight below broke off and sank into the deeper depths of the mantle,” says Russell Pysklywec, a professor in the department of Earth sciences and a co-author of the study.

“We now see the process is not a one-time tectonic event and that the initial drip seems to have spawned subsequent daughter events elsewhere in the region, resulting in the curious rapid subsidence of the Konya Basin within the continuously rising plateau of Türkiye.”

Andersen adds that the new findings suggest a connection between plateau uplift and basin formation events through the evolution of primary and secondary lithospheric removal. “Essentially, subsidence is occurring alongside the ongoing uplifting of the plateau.”

Andersen and study co-authors, including colleagues at Istanbul Technical University and Çanakkale Onsekiz Mart University in Türkiye, arrived at their findings after recreating the dripping process in laboratory experiments and analyzing their observations.

They built laboratory analogue models to establish how the process may have unfolded based on the data provided by the new measurements, filling a plexiglass tank with polydimethylsiloxane (PDMS) – a silicone polymer fluid approximately 1,000 times thicker than table syrup – to serve as Earth’s fluid lower mantle, adding a mixture of PDMS and modelling clay to replicate the upper-most solid section of the mantle, finishing with a sand-like layer on top made from ceramic and silica spheres to serve as Earth’s crust.

Artist’s impression of two types of lithospheric drip: one produces thickening and uplift of Earth’s crust, while the other results in the formation of a basin at the surface without horizontal deformation (illustration by Julia Andersen/91��Ƶ)

The researchers activated the model by inserting a high-density seed into the PDMS and modelling clay layer to initiate a drip that was subsequently pulled downward by gravity. A set of cameras were positioned above and beside the tank to record any changes over time, capturing a high-resolution image roughly every minute.

“Within 10 hours, we observed an initial phase of dripping, which we call a primary drip. After that primary drip touched the bottom of the box, we saw a second drip had begun to sink to the bottom after 50 hours,” says Andersen. “Both the primary and secondary drip were not causing any horizontal deformation in our artificial crust, which we expect is typically associated with a mantle lithospheric drip.”

The researchers already knew that the primary drip had caused changes in surface topography of the experiment, and wanted to know if the secondary drip would have any effect on the surface since it was a smaller sized drip than the primary drip. “What we noticed was that over time, this secondary drip did pull the crust downward and started to create a basin, despite no horizontal movements in the crust at the surface,” Andersen says. “The findings show these major tectonic events are linked, with one lithospheric drip potentially triggering a host of further activity deep in the planetary interior.”

'Narrative reversal' is key to telling a great story in books, films and TV shows: Study

Christopher.Sorensen — Tue, 17 Sep 2024 14:59:38 +0000

'Narrative reversal' is key to telling a great story in books, films and TV shows: Study

Christopher.Sorensen Tue, 09/17/2024 - 10:59

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(photo by Klaus Vedfelt/Getty Images)

Topic

Research & Innovation

Rotman School of Management

Subheadline

Researchers found that works featuring changes of fortune, or turning points, were more popular and received better audience reviews

Writers and scholars have long debated what makes for a great story, but Samsun Knight wanted to see whether there was a way to empirically determine which stories will be snore fests and which will leave audiences hungry for more.

Using a scientist’s tools, the novelist and economist found that “narrative reversals,” or peripeteias, were the key factor – lots of them and the bigger the better.

Samsun Knight (supplied image)

Commonly known as changes of fortune or turning points, where characters’ fortunes swing from good to bad and vice versa, Knight and his colleagues found that stories rich in these mechanisms boosted popularity and engagement with audiences through a range of media, from television to crowdfunding pitches.

“The best-written stories were always either ‘building up’ a current reversal, or introducing a new plot point,” says Knight, an assistant professor of marketing at the 91��Ƶ’s Rotman School of Management.

“In our analysis, the best writers were those that were able to maintain both many plot points and strong build-up for each plot point across the course of the narrative.”

The research, co-authored with Matthew D. Rocklage and Yakov Bart of Boston’s Northeastern University, was recently published in the journal Science Advances.

For the study, the researchers analyzed nearly 30,000 television shows, movies, novels, and crowdfunding pitches using computational linguistics, a blend of computer science and language analysis. The approach allowed them to quantify not only the number of a reversals in a text but also their degree or intensity by assigning numerical values to words based on how positive or negative they were.

Movies and television shows with more and bigger reversals were better rated on the popular ratings site IMDb. Books with the most and biggest reversals were downloaded more than twice as often as books with the fewest reversals from the free online library Project Gutenberg. And GoFundMe pitches with more and larger reversals were as much as 39 per cent more likely to hit their fundraising goals.

The Greek philosopher Aristotle was the first to identify peripeteia as a key feature of a good story, with Oedipus Rex serving as a classic example. Other thinkers have since added their ideas, including American playwright and dramaturg Leon Katz, whose scholarship particularly inspired Knight’s research.

“[Katz] described the reversal as the basic unit of narrative – just as a sentence is the basic unit of a paragraph, or the syllogism is the basic unit of a logical proof,” Knight says.

In addition to helping psychologists understand how narrative works to educate, inform and inspire people, the findings may also benefit storytellers of all kinds.

“Hopefully our research can help build a pedagogy for writers that allows them to rely on the accumulated knowledge of Aristotle et al. without having to reinvent the wheel on their own every time,” says Knight.

That includes himself. With another novel on the way, he was recently working on a chapter with a big reveal.

“I realized that this drop might hit harder if I gave the character more positive moments before pulling the rug out from under them.”

Researchers' lab technique could speed forensic analysis in sexual assault cases

Christopher.Sorensen — Tue, 17 Sep 2024 14:43:28 +0000

Researchers' lab technique could speed forensic analysis in sexual assault cases

Christopher.Sorensen Tue, 09/17/2024 - 10:43

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(photo by Science Photo Library/Getty Images)

Chris Sasaki

Topic

Breaking Research

Centre for Research and Applications in Fluidic Technologies

Institute of Biomedical Engineering

Donnelly Centre for Cellular & Biomolecular Research

Chemistry

Faculty of Arts & Science

Research & Innovation

91��Ƶ Mississauga

A team of researchers has developed a new approach to analyzing DNA evidence in sexual assault cases – one that could reduce lengthy delays in the processing of evidence.

While there are almost half a million sexual assaults in Canada every year, many more go unreported because victims are reluctant to come forward.

One of the reasons cited by victims is that analysis of forensic evidence is too slow.

Mohamed Elsayed (supplied image)

“For this research, we read reports and surveys that asked victims why they weren’t reporting assaults,” says the study’s lead author Mohamed Elsayed, who worked on the project as part of his PhD in biomedical engineering at the 91��Ƶ. “And the most common answer was that they didn't have confidence in the justice system – and that lack of confidence was partly because of how long the process takes.”

Elsayed, now a post-doctoral researcher in the department of chemistry in the Faculty of Arts & Science, co-authored the study with, among others, Leticia Bodo, a master’s student in the department of chemistry, and Aaron Wheeler, a professor in the department of chemistry, the Institute of Biomedical Engineering and the Centre for Research and Applications in Fluidic Technologies, a 91��Ƶ institutional strategic initiative.

All three researchers are also affiliated with the Donnelly Centre for Cellular and Biomolecular Research.

Processing forensic evidence in sexual assault cases is a technical, multi-step process that involves collecting DNA evidence and sending it to a well-equipped forensic laboratory for analysis by a skilled technician. Once there, the sample is first processed to isolate the assailant’s DNA from the victim’s so the assailant’s DNA can then be analyzed and used to identify a suspect.

The entire process can take days, weeks or longer. Most of that time is taken up with transporting the evidence to the lab, where its analysis can be further delayed depending on how many other cases are being investigated.

To speed things up, researchers focused on the first step: separating two individuals’ DNA from a single sample. At present, this is usually done manually by trained and experienced experts.

Elsayed and his collaborators, by contrast, developed a process called ’differential digestion” using digital microfluidics that helped simplify the overall process and reduce the number of manual steps needed to isolate the assailant’s DNA from 13 to five. “Also, because micro-fluidic processes tend to be faster, we expect that one of the eventual benefits will be shortening the overall time needed,” says Elsayed.

What’s more, the new approach could lead to a mobile solution that no longer requires a lab. For example, testing could be done at a hospital, circumventing the lab’s queue.

The new technique, described in a paper published in the journal Advanced Science, is compatible with the technology known as Rapid DNA analysis that is already in use for the second step of identifying an individual from their DNA. The study’s authors, which included researchers from 91��Ƶ Mississauga’s forensic science program, say the long-term goal is to integrate the two technologies to make the process even more streamlined.

While there remain several challenges to deploying the new technique, Elsayed says he is confident they can be overcome and has turned his efforts toward making it widely accessible and commercially viable.

“Our plan is to develop an instrument that will do in five minutes what currently takes 45,” says Elsayed. “And to run many more samples than previously. Once we do that, the next step would be to introduce the technology to forensic labs and hospitals.

“It will take years, but the potential is very exciting.”

The research was supported by the ANDE Corporation and NSERC Alliance Society.

"I’m grateful to NSERC for having the foresight to establish the ‘Alliance Society’ program which has a mission to ‘address a societal challenge that will result in new natural sciences and engineering knowledge and societal impact,” Wheeler says.

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Forensic Science

91��Ƶ engineering students encouraged to consider sustainability when designing future AI systems

Christopher.Sorensen — Mon, 16 Sep 2024 15:10:13 +0000

91��Ƶ engineering students encouraged to consider sustainability when designing future AI systems

Christopher.Sorensen Mon, 09/16/2024 - 11:10

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Professors Hans-Arno Jacobsen, left, and Natalie Enright Jerger of the Faculty of Applied Science & Engineering are part of a team that is training computer system designers to integrate sustainability practices into the development of AI and machine learning systems (photo by Jenny Lee)

Matthew Tierney

Topic

Our Community

Computer & Electrical Engineering

Faculty of Applied Science & Engineering

NSERC

Sustainability

Subheadline

The Sustainable Data Systems for Data Science initiative aims to align Canada’s tech investments with its vision for a carbon-neutral future

The growing global adoption of artificial intelligence technologies, including machine learning, has created a new sustainability challenge: AI systems are energy-intensive – and the more sophisticated they become, the more resources they require.

To help address the issue, a team of experts including the 91��Ƶ’s Hans-Arno Jacobsen and Natalie Enright Jerger – both professors in the Edward S. Rogers Sr. department of electrical and computer engineering at the Faculty of Applied Science & Engineering – are launching an initiative that aims to align Canada’s tech investments with its vision for a sustainable, carbon-neutral future.

The Sustainable Data Systems for Data Science (SDSDS) project aims to train a new generation of computer and data scientists who can combine comprehensive technical skills with sustainability awareness. The project recently received a $1.6-million Collaborative Research and Training Experience (CREATE) grant from the Natural Science and Engineering Research Council of Canada (NSERC).

“A majority of students are unaware of how sustainability informs responsible development of platforms and systems because, frankly, there just aren’t many courses or learning paths available to them in this area,” says Enright Jerger, who holds the Canada Research Chair in Computer Architecture and is director of the division of engineering science.

“Another crucial component of this project is to equip our students with knowledge transfer strategies so they can seed these ideas in the workforce. Today’s trainees becoming tomorrow’s trainers.”

The SDSDS team propose training future computer systems designers to adopt a green approach when developing data analytics platforms and systems. The approach would apply to all aspects of the life cycle of development and deployment – such as hardware infrastructure, software systems and application domains.

To advance knowledge and dialogue on the issue, SDSDS will look to hold cross-university seminars on sustainability challenges and will offer courses on sustainable data science, along with summer school programs focused on energy-efficient software and hardware platforms.

The researchers also aim to connect students with industry via internships and applied research projects, enabling them to gain exposure to current challenges and facilitate cross-pollination of knowledge between industry and academia.

“The awareness about AI’s environmental impact is growing, but there is an expertise gap on how to address this very real problem – not just after the fact, but at inception. SDSDS aims to bridge this gap and prepare for the future resource demands of AI-driven industries,” says Bettina Kemme, professor of computer science at McGill University and team lead at SDSDS, which also includes Semih Salihoğlu of the University of Waterloo, Oana Balmau of McGill University and Essam Mansour of Concordia University.

“The potential of AI and machine learning systems are seemingly limitless,” says Jacobsen, who is the Jeffrey Skoll Chair in Computer Networks and Innovation. “Yet the true genius lies in building machine learning systems founded on sustainability principles. That’s real innovation.”

Researchers develop new method for delivering RNA and drugs into cells

Christopher.Sorensen — Mon, 16 Sep 2024 15:02:15 +0000

Researchers develop new method for delivering RNA and drugs into cells

Christopher.Sorensen Mon, 09/16/2024 - 11:02

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PhD candidate Kai Slaughter, left, and University Professor Molly Shoichet are exploring how ionizable drugs can be used to co-formulate small interfering RNA (siRNA) for more effective intracellular delivery (supplied images)

Qin Dai

Topic

Breaking Research

Institute of Biomedical Engineering

Princess Margaret Cancer Centre

Temerty Faculty of Medicine

Donnelly Centre for Cellular & Biomolecular Research

Faculty of Applied Science & Engineering

Research & Innovation

University Health Network

Subheadline

"This could be a game-changer for treating complex conditions where targeting multiple pathways is beneficial, such as cancer and viral infections"

Researchers at the 91��Ƶ and its hospital partners have developed a method for co-delivering therapeutic RNA and potent drugs directly into cells, potentially leading to a more effective treatment of diseases.

The research, published recently in the journal Advanced Materials, explores how ionizable drugs can be used to co-formulate small interfering RNA (siRNA) for more effective intracellular delivery.

The team – including Molly Shoichet, the study’s corresponding author and a University Professor in 91��Ƶ’s department of chemical engineering and applied chemistry in the Faculty of Applied Science & Engineering – specifically targeted drug-resistant cells with the delivery of a relevant siRNA. The siRNA was discovered study co-author and collaborator David Cescon, a clinician scientist at the Princess Margaret Cancer Centre, University Health Network, and an associate professor in 91��Ƶ’s Temerty Faculty of Medicine.

“We found that our co-formulation method not only potently delivered siRNA to cells but also simultaneously delivered active ionizable drugs,” said research lead author Kai Slaughter, a PhD candidate in Shoichet’s lab.

“This could be a game-changer for treating complex conditions where targeting multiple pathways is beneficial, such as cancer and viral infections.”

siRNA is a powerful tool in medicine, capable of silencing specific genes responsible for disease, but delivering these molecules into cells without degradation remains a significant challenge. While recent innovations in ionizable lipid design have led to efficiency improvements, traditional nanoparticle formulations are limited in the amount of small molecule drugs they can carry.

When therapeutic formulations are absorbed by cells, small molecule drugs and siRNA are often trapped in small compartments called endosomes, preventing them from reaching their target destination and reducing their effectiveness.

The research team discovered that combining siRNA with ionizable drugs – compounds that change their charge based on pH levels – enhances the stability and delivery efficiency of siRNA inside cells, helping both the siRNA and drug escape the endosome and more effectively reach their destination. This novel method utilizes the protective properties of lipids to safeguard siRNA during its journey through the body and ensure the release of RNA and the drug together within the target cells.

“One of the biggest hurdles in siRNA therapy has been getting these molecules to where they need to go without losing their potency,” Shoichet says.

“Our approach using ionizable drugs as carriers marks a significant step forward in overcoming this barrier, while also showing how drugs and RNA can be delivered together in the same nanoparticle formulation.”

3D-printed soil? 91��Ƶ startup expands sustainable urban farming footprint in Toronto

Christopher.Sorensen — Wed, 11 Sep 2024 15:07:18 +0000

3D-printed soil? 91��Ƶ startup expands sustainable urban farming footprint in Toronto

Christopher.Sorensen Wed, 09/11/2024 - 11:07

Cutline

Leo Hua and Adnan Sharif show off fresh basil that was grown with Lyrata’s sustainable farming system at Toronto’s Casa Loma (photo by Liz Intac)

Topic

Entrepreneurship Hatchery

Faculty of Applied Science & Engineering

Innovation & Entrepreneurship

Startups

Sustainability

91��Ƶ Scarborough

Subheadline

With new installations at Casa Loma and 91��Ƶ Scarborough, Lyrata is supplying freshly grown produce to local caterers and restaurants

A startup co-founded by a 91��Ƶ graduate student has its roots in an experience that is all too common for many of us.

He kept forgetting to water his plants.

“I was working in a plant immunity biology lab, so if I didn’t water them, I’d have no plants to do experiments with,” says Adnan Sharif, who is pursuing a master’s degree in the department of chemical engineering and applied chemistry in the Faculty of Applied Science & Engineering.

He says his solution was inspired by his father.

“My dad is a mechanical engineering professor at a university in Japan, and he knows a lot about manufacturing materials with porous, three-dimensional structures,” he says. “That’s how I got the idea to make my own 3D-printed soil construct, which could retain water for a week or more.

“That way, I wouldn’t have to go into the lab and water the plants so often.”

The innovation – which Sharif came up as an undergraduate working in the lab of Keiko Yoshioka, a professor in the department of cell and systems biology in 91��Ƶ’s Faculty of Arts & Science – is one of several that now underpins Lyrata, a startup that grows fresh produce for caterers and high-end restaurants across the Greater Toronto Area.

The company, which got its start in a greenhouse on 91��Ƶ’s St. George campus, has recently expanded with operations at 91��Ƶ Scarborough and Casa Loma, a museum, event space and historic site in midtown Toronto.

Growing plants without soil, known as hydroponics, is a technique commonly used in greenhouses worldwide. But Sharif and his team see an opportunity to make the industry more sustainable, starting with the soil replacement that the plants grow in.

“The product that almost everyone uses today is basically the same as house insulation,” Sharif says. “It’s made from rocks that are mined in remote places and shipped hundreds of kilometres to a production facility, where they are heated to thousands of degrees in a giant furnace to make a porous, chemically inert material. This material then needs to be shipped again to where it’s needed, and when you’re finished, you throw it in the garbage.”

By contrast, Lyrata’s SmartSoil is 3D-printed using biopolymers such as polylactic acid, which is derived from corn. These materials can be locally sourced and require much lower temperatures to melt and form into porous structures.

When the growing cycle is complete, the product goes through a low-heat proprietary cleaning process and can be used again. Sharif says that SmartSoil has a total lifespan of about two years, after which it can be composted along with crop residue. Together, these changes greatly lower the carbon footprint of indoor farming.

In 2020, Sharif and his co-founders brought his idea to The Entrepreneurship Hatchery, 91��Ƶ Engineering’s startup incubator and one of several entrepreneurship hubs across 91��Ƶ’s three campuses. Through the Hatchery’s Nest process, they were connected with business mentors, including alumnus Xavier Tang, a consultant and venture capitalist who still advises the company today.

Over the next few years, the team evolved, with some original members leaving and others joining. They include Leo Hua, who has been pivotal to speeding the development of 3D printable soil. The concept evolved, too, as the team realized that producing food was a better business for Lyrata than rather than selling their growth medium to other farmers.

The Hatchery team – in particular, Executive Director Joseph Orozco, Go-To-Market Lead Erika J. Murray and a team of work-study students, mentors and legal externs – helped Lyrata develop their technology and business. In 2022, the Hatchery provided $155,000 in seed funding, enabling the founders to be employed by their company and further supporting business development. The funding also enabled the company to rent greenhouse space on campus, where they began growing lettuce to provide to Spaces and Experiences at 91��Ƶ.

Lyrata also developed something new: a modular unit that works exclusively with their SmartSoil and contains everything required to produce a variety of indoor crops – from lights and growth medium to irrigation systems.

“None of these technological and business developments would have taken place without the generous support of the over 50 Hatchery mentors, work-study students, and legal externs who contributed to our success,” says Sharif.

“Our current concept is what we call farming-as-a-service,” Hua adds. “The SmartGrow unit we developed is small enough to fit into a standard parking spot. Our clients sign a contract with us to place a unit on their site and we take care of everything from planting to harvesting.

“For a flat fee, they get a self-contained farm that provides a reliable quantity of their desired crop over a set period of time.”

In addition to providing a locally sourced, sustainable product, Sharif says the approach can also help mitigate fluctuations in the price of wholesale produce.

“In Canada, most of our lettuce comes from California, which has been dealing with drought and many other issues,” says Sharif. “Supply chain disruptions due to COVID-19 were also a big challenge for restaurants, which have very thin margins to begin with. At one point, the price of lettuce increased by a factor of six, so you can imagine the effect that would have.”

So far, Lyrata has produced more than 15 different types of crops, including basil, parsley and mizuna, also known as Japanese mustard greens.

Support from the 91��Ƶ Engineering community has been key to Lyrata’s success.

For example, it was a 91��Ƶ Engineering alumni connection that recently led to Lyrata launching an installation at the historic Casa Loma museum and landmark in Toronto.

“Lyrata’s competitive edge is that they provide an on-site, full service and they do not take up very much space,” says Nikol Watlikiewicz, Casa Loma’s horticulture and grounds manager. “In a small corner of our potting shed, we were able to build two grow units that provide a good yield weekly, without having to train our staff on the complicated system.

“Growing indoors gives us the stability and control that traditional agriculture does not. It’s an excellent example of how engineers can help solve the global food crisis with innovative thinking.”

In August, Lyrata launched another growing unit at 91��Ƶ Scarborough, located within the Harmony Commons Dining Hall.

The priority for the next few years is growing Lyrata’s crop offerings and client base with ongoing support from The Hatchery. The incubator has facilitated graduate student placements through Mitacs, with matching funds. It also backed a recent $167,500 project with the Ontario and Canadian governments through the Sustainable Canadian Agricultural Partnership program to further advance the yield and efficiency of the SmartSoil system.

“The fact we’ve been able to come this far in such a short time is in large part due to the help we’ve had from 91��Ƶ Engineering, and especially the Entrepreneurship Hatchery,” says Sharif.

“Whether it was getting seed funding, finding mentors, hiring work-study students or making important connections through their alumni network, we wouldn’t be here without their support.”

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3D-printed soil? 91��Ƶ startup expands sustainable urban farming footprint in Toronto